Kinder Ground for Animal Welfare – Interview with Dr. Jennifer Walker

Kinder Ground for Animal Welfare – Interview with Dr. Jennifer Walker

California Dreaming

A veterinarian by trade, Dr. Walker (Dr. Jen) grew up south of San Francisco determined to be a veterinarian, specifically one that specialized in cancer treatment. As an animal science major at UC Davis, she realized that the chances of her finding breakthrough cancer treatments were slim and more importantly, through her volunteer work in the oncology ward she “began to struggle with the amount of suffering we were asking these pets to go through for their owner’s struggle with letting go”.

Working on the university dairy she also realized that while there were a lot of folks lining up to be small animal veterinarians, few wanted to work with food animals and began to think that working in food animal medicine is where she could make a real difference explaining “I enjoyed the people we worked with, and I enjoyed being outside. In food animal medicine you get to see your clients more frequently, you get to be a part of their team, and not just see them when disaster struck.” It was then Dr. Jen made the decision to go all into food animal medicine.

While she was confident, the vet school wasn’t. She had to apply 4 times before she was accepted to vet school. On the third “rejection” she was told they doubted her interest in food animal medicine. Still a bit resentful of the judgment, she admits it did force her go out and get more experience outside of the bounds of the university. She never gave up and was finally accepted, graduated in 2000 in joined a small practice in San Joaquin County California focused on dairy production medicine where they were part of the farm team, training, teaching and consulting, and she loved it.

Look What You Made Me Do!

As much as she enjoyed practice and her clients, it became clear that the work can take a toll on the body. She had long considered returning to the university to teach, wanting to bring practical, real-world experience to the clinical teaching environment. She made the leap and returned to UC Davis for a residency. She loved work and the students but soon realized that if clinical teaching was the goal, a PhD was the next step to ensure she would be competitive in that environment. She was lucky enough to find a funded PhD program focused exactly on what she was interested in at the time, udder health, specifically Staph aureus mastitis. So, it was off to Ohio.

It was at The Ohio State University that Dr. Jen developed an interest in animal welfare. She explained that “sadly, animal welfare just wasn’t something taught in veterinary medicine prior to 2008.”  It was in 2008 that undercover video exposed the cruel handling of non-ambulatory cattle at the Hallmark/Westland meat packing company. “That was the beginning of what I call the beginning of our reputation era” she said explaining “the animal welfare discussion started bubbling up. I had an office mate with a small animal background that would see one under cover video after another and come to me upset and with lots of questions. We had lots of great chats about animal welfare and animal agriculture. That is when animal welfare science caught my focus and really opened some doors for me.” As luck would have it, Dr. Jen was also studying education as a minor and used that as a vehicle for her animal welfare studies working with faculty to develop a course in animal welfare and her career in animal welfare blossomed from there.

From the Barnyard to the Boardroom and Back Again 

After finishing her PhD with a passion and focus on animal welfare, in 2010 Dr. Jen joined Dean Foods, at that time the largest dairy processor in the United States as Director of Dairy Stewardship. There she developed and managed an industry leading animal welfare program, before moving on to Danone North America where she managed milk quality and animal welfare in 2018. Along the way she managed to earn a master’s in Animal Welfare, Ethics and Law through the University of Edinburgh and applied those learnings to her work in the corporate arena.

During her stint at Danone, she gained new perspective on what could and could not be accomplished through industry, corporate and legislative animal welfare initiatives. From that experience grew a passion project she co-founded, Kinder Ground, a no-profit dedicated to helping farmers implement practices on farms that improve animal welfare. She recalls, “When I was working in corporate, one of the challenges I saw was that projects were driven by what the corporation was focused on and what they were prioritizing at that time. As soon as the corporation got sidetracked or management changed there was nothing to sustain the effort. When the corporation dictates what happens on the farm, it’s just a box to check, not something that is valued by the farmer.”

The purpose behind Kinder Ground is to bring together the farming community. The theory of change is understanding that there are improvements needed in the lives of farm animals, and those improvements and changes are most successful when they come from ideas straight from the farmer. Reflecting, Dr. Jen shared, “Over the years I had seen so many projects abandoned, because it wasn’t the farmer driving the change. I truly believe that farmers will have the best ideas. The void that Kinder Ground is filling is how do we put science into practice. We are that link from science to implementation on the farm. Farmers have the imagination, the gumption, and the creativity to figure out how to make it work. We also know that farmers talk to farmers. This is how welfare improvement becomes contagious, when they see the benefits of the improvements made by their neighbors. Let farmers amplify the message!”

Sowing Seeds of Compassion 

Having donated the seed funding to get the non-profit and projects started, and lucky enough to have built enough savings, Dr. Jen stepped away from Danone at the end of 2023 to dedicate herself full time to Kinder Ground without even drawing a salary. Her goal is to focus on Kinder Ground for three years and get it to a place where it can financially sustain itself.

Dr. Jen explained that the biggest challenge to getting farms started on projects is the risk of failure. Kinder Ground makes that risk a little more palatable. Farmers don’t give themselves enough credit, they are swimming in risk and unknown every single day. I am always amazed at the level of risk they take on. What we found is that if we can partially support a welfare project it is a lot easier to take that leap, knowing that there is risk that our project might fail, but we can give it a go together. Kinder Ground is also hoping to show those outside the industry that many farms want to make improvements in animal welfare, but it’s not something that can be done with a cookie cutter approach. “Improving welfare looks a little different for each farm. We can’t cookie cutter a life worth living, and we aren’t going to be successful by mandating it. You can mandate tail docking, basic care, pain management, but elevating welfare to a life worth living is advancing past the basics. That is going to be a farm-by-farm process.”

Show Me the Money!

Dr. Jen admits that it is hard to capture in a spreadsheet the financial return on improvements in animal welfare.  Animal welfare is a long-term outcome that gets washed out in the details of a quarterly P&L. Kinder Ground asserts that practical animal welfare is about acknowledging trade-offs and realizing better is better, that even small investments and changes can have a real impact. Dr. Jen goes on to challenge consumers and all business, “If dairy, beef, or pork, or chicken is on your menu, you should be doing something to enable farmers to improve animal welfare. I see millions of dollars wasted on the supply chain side of things, meant to improve welfare, but really doing nothing. It usually ends up being audits, surveys, or messaging around welfare, but not a single penny of it has improved the welfare of livestock animals.”

What started out as a passion project, Kinder Ground is hoping that the supply chain jumps on for support. Dr. Jen is emphatic about the message and challenge to the supply chain, saying “Millions of dollars have been wasted on messaging and halfhearted programs. All we have managed to do is set a very low bar of, don’t be cruel, and relatively little improvements have been made beyond that. I want to change the habit of putting messaging over impact, and checking boxes. We can do so much good when we focus the resources on making a difference.”

A big thank you to Dr. Walker for taking the time to chat with us about animal welfare!  If you are looking for welfare resources, have the desire to implement a welfare project, or if you would like to donate to Kinder Ground, please visit their website KinderGround.org. Let’s help to make life worth living for our food animal species!

Prevention of Foodborne Illness Starts at the Farm Level

Prevention of Foodborne Illness Starts at the Farm Level

The Centers for Disease Control and Prevention (CDC) has identified nontyphoidal Salmonella as one of the top 5 pathogens contributing to foodborne illnesses in the United States. Ground chicken leads the pack when it comes to Salmonella contamination, but ground beef is also a common source of Salmonella outbreaks.

Illness caused by Salmonella is an ongoing issue. Despite the goal to reduce foodborne Salmonella infections as part of the initiative of the Healthy People Objective between 2010-2020, incidence did not decline. In 2008 there were 15 Salmonella infections per 100,000 people and in 2019 Healthy People reported 17 infections per 100,000 people.

 

Salmonella in Beef Products

Salmonella is known to be a dreaded enteric pathogen causing calf scours, but it is also problematic on the harvesting end of things because of the potential risk to humans. From 2012-2019 it was estimated that beef was the source of 5.7-9.1% of all foodborne Salmonella illnesses, averaging 4 outbreaks, 91 illnesses, and 16 hospitalizations per year.

Foodborne illness outbreaks from Salmonella are most likely to happen in the warmer months of the year, and December during holiday celebrations. Although much of the risk of an outbreak depends on food handling, however, contamination prevention starts at the animal level. Contamination begins when Salmonella from the GI tract comes in contact with the carcass surfaces during slaughter and processing.

 

Reducing Transmission

– Protect breeding stock from Salmonella infection.

Routine surveillance and testing are key as is removal of infected animals.

-Prevent contamination of feed and water.

This may include heat treatment of feed, incorporation of organic acids, bacteriocins, and or acidifiers to feed and water.

– Implement biosecurity protocols.

– Control rodents, insects, and wild birds.

– Prevent Salmonella infection.

Vaccination and antibiotic use as directed by a veterinarian may reduce the Salmonella load in livestock animals.

– Reduce animal stress.

Stress increases the shedding of Salmonella and increases the risk of infecting other animals.

Segregate herds with high vs. low Salmonella infection rates during transport.

Clean and sanitize containers and trucks used to transport animals.

Improve animal hygiene.

 

Feeding strategies

A well-established microbiome proves helpful in keeping Salmonella infections at bay. Beneficial microbes competitively exclude pathogenic strains from colonization. However, stress or other environmental factors may contribute to gut dysbiosis which leaves the animal vulnerable to pathogen growth.

Feeding strategies that include binders, probiotics, and prebiotics may help to reduce the pathogen load, and enable the immune system to fight off the remaining offenders, repair any damage done to the gut tissue, and result in a complete resolution of inflammation.

– Antibodies: bind Salmonella through antigen specificity, isotype profile, Fc-gamma receptor usage, and complement activation.

– Probiotics: Bacillus subtilis outcompetes pathogenic bacteria from colonizing the intestinal wall. Bonus, it produces large amounts of digestive enzymes to help with feed conversion.

– Mannan oligosaccharide (MOS): decreases prevalence of intestinal pathogenic bacteria and improves immune defenses.

– Yeast Culture: enhances rumen function, improves digestibility, dry matter intake, and helps relieve heat stress.

– Biologically active polysaccharides: ensure that immune function is at peak performance!

– Zinc Methionine: improved gut mucosal layer, improved feed efficiency, lung and hoof health.

 

Two of my favorite feed supplements that include many of the strategies listed above are Surveillance Calf and TomaHawk iL. In a study prepared by Alfonso Lago, DVM, Surveillance Calf and TomaHawk iL were found to bind over 40% of Salmonella Dublin, Newport, and Typhimurium at the normal daily feeding rate. Pathogen reduction at the therapy level of both products bound 100% of Salmonella Dublin, Newport, and Typhimurium.

Calf raisers, beef, and poultry producers have the ability to make a huge impact on the level of Salmonella contamination that we have in our food system. Education and resources like Surveillance Calf and TomaHawk iL are necessary for pathogen control if we are going to effectively reduce incidence of contamination and improve meat quality for the consumer.

 

Written by: Mariah Gull, M.S.

Sources:

salmonella-fact-sheet-2015.pdf

Salmonella Outbreaks Linked to Beef, United States, 2012–2019 – ScienceDirect

Welcome Bret Hobbs to MicroBasics

Welcome Bret Hobbs to MicroBasics

Bret Hobbs grew up in a farming and ranching background. He grew up in West Texas, however, his father leased a ranch in New Mexico and each summer Bret was busy helping his father run 10,000 head of stockers on the ranch. It was a great way for a young man to grow up, he spent his summers riding, roping, and caring for the cattle.

Bret chose to study Agriculture Education, completing both a bachelor’s and master’s degree in that area of study. But all it took was one year of teaching in a new ag program in a rough area of Houston, TX and Bret new it wasn’t where he was meant to be. He moved back to Lubbock and pursued other avenues.

Bret served for 15 years as a meat inspector. It got to the point that the only way he could progress in that line of work would be to earn a degree in veterinary medicine. When Bret was ready for a change, he took a job with Dairy Max and worked in dairy promotion for 5 years. Upon leaving Dairy Max, Bret, entered the world of sales, he has sold ear tags, pharmaceuticals, hormones, electrolytes, and has managed a distribution route. We are excited to have Bret join the sales team at MicroBasics!

More about Bret to follow……

Q: What are your hobbies and interests?

A: I am a big fan of Texas Tech Sports, I enjoy following the teams and watching the games. I enjoy playing golf, my youngest son played golf in high school and it’s something we enjoy doing together. I am also very involved in the youth group at my church, I enjoy participating in activities and trips with them.

Q: What is something you have learned in your previous work experience, that you feel has a big impact on livestock health and productivity?

A: In my most recent position at Tech Mix, I dealt a lot with helping animals deal with stress and setting the animal up for success through electrolyte balance. I think that is something that will continue to relate to how I serve cattle producers through MicroBasics and is synergistic to our focus on immunity and gut health.

Q: What service are you most excited to provide cattle producers in your new role at MicroBasics?

A: I am very excited to provide cattle producers with a lineup of products that have a synergistic approach, provide solutions to multiple issues, and result in a cascade effect when it comes to animal health.

Q: What part of the country will you be working in?

A: I will be serving beef and dairy customers in Texas, New Mexico, Kansas, Colorado, and Arizona.

We are excited to have Bret on board at MicroBasics! Please don’t hesitate to reach out to him if you have a need.

Written by: Mariah Gull, M.S.

Raising Sheep with the Lister Family

Raising Sheep with the Lister Family

Laura Lister grew up in Emery County, Utah, and had nothing to do with sheep until she met her husband in 2006. He grew up herding and shearing sheep with his family and Laura grew up with strictly horses. Laura chose to study animal science in college with an emphasis in equine science due to her background. She graduated with a bachelor’s degree in Animal Science from Southern Utah University.

When the Lister’s moved to Sanpete County Laura worked as a paraprofessional for a while until she started having children. When her boys were both old enough to be in school, she went back to work as a paraprofessional. Within a month she was offered a job as a 3rd Grade teacher. At the time there was a program called Alternate Pathways to Licensure available for teachers to become licensed if they had a bachelor’s degree in any subject. It was baptism by fire those first few years and she taught and took some classes herself to become a fully licensed teacher. She loves her job and is teaching 2nd grade this year.

Laura’s husband ran a 10-man shearing crew for quite a few years and in 2010 the Lister’s decided they wanted to start raising their own sheep. They started small with just 15 ewes, but it has boomed into their own little herd of 200 head now. They run mostly white-faced breeds, but also have some black-faced club lambs for their boys to show in 4-H.

Laura was kind enough to share some thoughts with us about what it entails raising sheep in the current marketplace.

 

Q: How has marketing your sheep changed over the past 5-10 years?

A: Most of our lambs are sold and shipped right off the ewe, but the last few years we have started finishing some out for our local farmer’s market meat shop.

 

Q: What factors influence the profitability of the lambs you sell?

A: We try to get the lambs that we sell to the farmer’s market heavier faster. Those lambs are going straight to the butcher whereas our fall weaned lambs we try for even weights so we are selling a consistent group.

 

Q: What are some obstacles that you see coming in the near future for sheep ranchers or for those that want to get into the sheep business?

A: One of the hardest is, don’t quit the first time you have a bad year. There will be times you will just want to walk away. It’s hard and costs fluctuate. One year you might sell your lambs for $2.00 per pound and the next year you might only get $1.75 per pound. The first couple of years getting into it will be hard. If you can financially make it work keep going. We need people in agriculture!

 

Q: Where do you run your sheep?

A: We run everything on private land. Just the fields around our place. We are lucky we have the pastures we do.

 

Q: How do you handle and feed your sheep around lambing?

A: We have creep feeders for the lambs, so the ewes don’t eat all their food. There is chopped hay in the creep feeder. Chopping the hay helps them eat all the hay and not just the leaves. We feed the ewes a little supplemental whole corn or flaked corn while they are nursing their lambs. Creep feeding the lambs helps them get to eating the corn faster. We also have salt licks, minerals, and lick tubs available for them.

 

Q: How do you involve your entire family?

A: Everything we do is just the 4 of us. Our two boys can lamb and do everything else that is involved in raising sheep. It has opened a lot of doors for them. hey know how to work hard, they raise their own 4-H lambs, and my oldest recently applied for a program through the Targhee Sheep Association to get 5 ewes to start his own flock with. If he is selected there are requirements he will have to fulfill and report back to them about how things are going after he gets started.

 

Thanks, Laura, for all the great thoughts about families involved in agriculture and raising sheep! We appreciate your time and wish the Lister family the best of luck in their family operation!

 

Written by: Mariah Gull, M.S.

Supplementation of Active Dry Yeast

Supplementation of Active Dry Yeast

Direct fed microbial (DFM) products are one possible avenue to improve animal health during the transition period. Active dry yeasts (ADY) are one subset of DFM. ADY have been found to act growth promoters and influence immune function in several species.

Mechanisms

The mode of action for ADY are wide and varied. ADY have been shown to impact lactate and lactic acid production, increase feed digestibility and efficiency, decrease oxygen and improve fermentation and feed breakdown in the rumen.

Benefits

The positive effects of feeding active dry yeast are dependent on diet, formulation, and concentration, and can vary from farm to farm. The documented benefits are listed below.

  • In beef steers, feeding ADY showed an improvement in immune response via an increase in TLR-4 expression.
  • In the lower gut ADY may inhibit pathogen growth, stimulate an immune response, and balance microbial growth.
  • S. cervesiae boulardii has been found to have protective effects on the small intestine in calves and reductions in pathogen load. Ultimately reducing inflammation.
  • Improved milk yield and decreased body losses in the first 7 weeks of lactation, without impacting dry matter intake (DMI).
  • Protection of the lower gastrointestinal tract.
  • Increased crypt depth and width in calves.
  • Improved tight junction structure and mucin production.
  • Improved innate immune response.
  • Improved nutrient digestibility

Phenotypes

Yeast phenotypes are diverse and encompassing. The S. cervesiae family alone includes at least 74 phenotypes grouped into 10 different categories. In ruminants, different strains of S. cerevisiae can change the rumen fermentation profile to a more acidotic and glucogenic state, and/or impact fiber digestion.

It is still unsettled whether S. boulardii is a substrain of S. cerevisiae or a separate species all in itself.  Either way, S. cerevisiae boullardii (SCB) is known to impact intestinal mucosa, modulate immune response, gene expression, and protein synthesis.

An activated immune response increases energy demand up to 55%, the equivalent to 1 kg (2.2) lbs. of glucose in a 12 hour period of time. Alterations made by SCB to the immune response may result in energy savings that would leave more glucose available for growth and without increasing DMI. More research is needed to fully understand the mechanisms of metabolism while feeding SCB or other strains of ADY, but in the short term we are seeing benefits to animal health and production so supplementation may become a more popular avenue in improving animal health and maximizing production.  For more information on how we utilize ADY and SCB please email us at service@microbasics.com.

Written by: Mariah Gull, M.S.

Sources: Effects of Saccharomyces cerevisiae boulardii (CNCM I-1079) on feed intake, blood parameters, and production during early lactation – PubMed

Gut-Organ Axes: The Gut-Lung Connection

Gut-Organ Axes: The Gut-Lung Connection

One of the more recently discovered gut-organ connections is the gut-lung axis. Originally lungs were thought to be sterile unless an infection was present. This was due mostly to the fact that researchers were not able to culture microbes from the lungs of healthy animals. Utilization of new technologies in 16s rRNA gene sequencing have allowed researchers to discover that the lungs of healthy individuals are inhabited by a community of commensal microbes which play a role in protecting the respiratory tract from disease causing pathogens and activation of both innate and adaptive immune responses.

Respiratory Tract Development

The respiratory tract is divided into 2 parts: the upper respiratory tract (URT) and the lower respiratory tract (LRT). The nasal cavities, paranasal sinuses, nasal passages, nasopharynx, oropharynx, tonsils, and upper portion of the larynx make up the URT. The LRT contains the lower portion of the larynx, trachea, bronchi, bronchioles, and alveoli.

The URT and LRT are colonized by different microbes shortly after birth. The microbial population of the LRT are mostly Bacteroidetes and Firmicutes, which is most like the oral cavity which suggests that the oral cavity microbiota may play a role in the establishment of the lung microbiota.

The microbiota of the nasal cavity (a portion of the URT) consists mostly of the phyla Firmicutes and Actinobacteria, like the microbial population of the skin.  Researchers are still learning but have discovered that the microbial communities of the URT and LRT are known to influence each other. Many factors play into the development of commensal microbial communities including diet, genetics, age, vaccination, management, and environment.

Lung Defense

The first line of immune defense within the respiratory tract is the nasopharyngeal mucosal layer which captures inhaled particles and prevents them from moving back up into the nasal and oral cavities. The mucus layer contains immune cells including antimicrobial peptides, glycoproteins, and IgA which help maintain homeostasis of the respiratory microbiota.

The second line of defense is the mucosal epithelium which produces molecules that trigger innate and adaptive immune responses to improve barrier function. The commensal microbes of the respiratory tract, mucosal epithelium, and the immune system communicate to promote respiratory health, reduce inflammation, and maintain functioning microbiota populations.

Gut-Lung Communication

Signaling that travels the gut-lung axis is bi-directional, however, most of the communication between the microbial populations of the gastrointestinal tract (GIT) and the respiratory tract travels from the gut to the lungs. The specific mechanisms involved are still unknown. Furthermore, the lymphatic system and the bloodstream also play important roles in this communication by carrying bacteria and bacterial metabolites from the GIT to the lungs.

Short chain fatty acids (SCFA) are one of the main ways that GIT microbiota influence the immune system, and thus the respiratory tract. SCFA are important for maintaining intestinal integrity and preventing inflammation in both the gut and the respiratory tract. SCFA also increases IgA production by enhancing plasma B cell metabolism ensuring that the intestines are protected from inflammation. Supplementation of prebiotics to increase SCFA production may prove helpful in improving epithelial integrity as well as improve the animal’s immune defense mechanisms.

On Farm Application

Bovine Respiratory Disease (BRD) is one of the most significant health concerns for weaned calves and feedlot cattle. Even with years and years of research in management and vaccines, BRD still remains one of the leading causes of morbidity, mortality, welfare concern, and economic losses within beef production.

BRD is a result of a combination of factors including environment, stress, management, and nutrition. The pathogens causing BRD are common commensals of the URT(e.g., Mycoplasma, Mannheimia, Histophilus, and Pasteurella). Microbiota of both healthy and sick animals can translocate from the URT to the LRT through inhalation after the host undergoes a stressful event.  The result is the development of pneumonia. Since stressful events contribute to the development of respiratory disease, composition of GIT microbiota may prove helpful in decreasing the incidence of BRD.

Research has shown that dietary supplementation can influence GIT microbiota, which also impacts the respiratory microbiota. The inclusion of minerals essential to the immune system are helpful as well as probiotics, prebiotics, and post biotics that bolster the microbial population, support intestinal epithelial integrity, and enhance immune function.

A trial including 1,374 calves showed a 15.4% reduction in BRD Treatment for those calves receiving TomaHawk iL Zn (a natural supplement that modulates inflammation, influences the GIT microbiota population, and includes other functional minerals and components that influence immune function).  he reduction in BRD treatments, as well as decreases in GIT disease and mortality equated an economic advantage of $5.34/animal.

How will knowledge of the gut-lung connection change the livestock industry?  Well, hopefully we can approach respiratory disease more proactively than reactively. In the trial mentioned above, TomaHawk iL Zn was successful in decreasing respiratory disease, antibiotic use, and death loss. The result, healthier more profitable animals. Time will tell, but I hope to see GIT management become a tool on more and more farms each year.  As the trend continues maybe we will finally make some headway against BRD.

Written by: Mariah Gull, M.S.

Source: Welch CB, Ryman VE, Pringle TD, Lourenco JM. Utilizing the Gastrointestinal Microbiota to Modulate Cattle Health through the Microbiome-Gut-Organ Axes. Microorganisms. 2022 Jul 10;10(7):1391. doi: 10.3390/microorganisms10071391. PMID: 35889109; PMCID: PMC9324549.

Importance of a VCPR

Importance of a VCPR

A Veterinarian-Client-Patient-Relationship (VCPR) is an agreement between a Veterinarian of Record (VOR) and a livestock producer which allows the producer access to expertise in animal health and prescription medications when deemed necessary by the VOR.

VOR

All livestock producers should have a valid VCPR. The VOR has the responsibility for providing oversight of treatment protocols, drug inventories, drug usage, prescription medications, and employee training.

  • The VOR listed on the agreement must consent to the role.
  • Be familiar with the facility.
  • Have been on site in the past 12 months.

Expectations

Expectations for a VCPR include:

  • Written agreement with the veterinarian which identifies the farm veterinarian accountable for drug use and treatment administration.
  • The VOR is responsible for overseeing drug use. Including tasks such as establishing treatment protocols, employee training, record analysis, and monitoring drug inventories.
  • Regular farm visits are critical to a VCPR. Time between visits should be decided by the VOR and be based on the size of the operation.
  • Other veterinarians that provide professional services must contact and inform the VOR of their findings and recommendations.
  • Written or electronic treatment records of all animals treated are pertinent in maintaining the VCPR. Said records should include the date, animal ID, drug(s) used, frequency, duration, dose, method of administration, applicable meat or milk withdrawal intervals, and the person giving the treatment.
  • The sale of drugs is not a valid ethical reason for having a VCPR.

Benefits

Your veterinarian can be a beneficial resource in establishing, reviewing, and improving protocols. They can help you identify management gaps and protocol drift with the goal of improving animal health and productivity.

  • Use your veterinarian as a resource for training employees.
    • Potentially painful procedures.
    • Disease identification.
    • Medication and treatment protocols to maximize recovery success.
    • Antibiotic stewardship.

Having a licensed veterinarian on your management team can bring a lot of resources to the table for your livestock production system. If you haven’t already established a VCPR talk to your veterinarian about doing so and use the program to help encourage record review and protocol improvement.

Written by: Mariah Gull, M.S.

Managing Biotoxins – Endotoxins

Managing Biotoxins – Endotoxins

The worldwide economic damage caused by endotoxin contamination is overwhelming. Effecting all livestock sectors including dairy, beef, poultry, swine, sheep, goats, egg production, and aquaculture. Economic losses are influenced by production losses, higher mortality rates, increased treatment costs, and increased management costs.

There are many different causes behind high endotoxin loads. Factors such as high-energy diets, high temperatures, birth, rehousing or pen movements, and antibiotic treatments.

Identification

Endotoxins are the main component of the outer cell wall membrane of Gram-negative bacteria. Their main function is structural and protective. Frequently the word endotoxin may be used interchangeably with lipopolysaccharide (LPS).  Endotoxins are released when the bacteria cell dies, is mechanically damaged, or during cell lysis during bacterial growth and division.

For both humans and animals, endotoxins induce different biological reactions when present in even small amounts. Endotoxins can be found in the water, air, and environment. They are heat-stable and can exist even after sterilization.

Detection of endotoxin contamination in animals is challenging for livestock producers. Unlike mycotoxins, endotoxin levels are difficult to measure on the farm. Harmful effects of endotoxins may show up as increased infections, diarrhea, circulatory disorders, necrosis, pain, poor growth, or even reduced product quality. Most of the time the cause goes unrecognized, which leads to ineffective treatments.

Toxicity

When endotoxins are exposed on the surface of the bacteria, the innate immune system recognizes them as a threat and reacts accordingly. When Gram-negative bacteria are killed by the immune system, fragments of their membrane containing endotoxins are released into the blood stream and may cause fever and/or diarrhea.

Presence of endotoxins in the blood (endotoxemia) may lead to hypotension, respiratory failure, reduced oxygen delivery, sepsis, and even death.

Sources of Endotoxin

Gastrointestinal Tract: changes in the microbial community when cattle shift from a high-forage diet on a high-grain diet depresses rumen pH and increases LPS concentrations. LPS can cross the intestinal epithelium and disrupt intestinal barrier integrity.

Mammary Gland: bacterial infections of the mammary gland can end up with LPS translocation into systemic circulation.

Uterus: Bacterial contamination of the uterus occurs in most cows after parturition. Yet another potential source of endotoxin contamination. Cows with more severe uterine infections will be more at risk for endotoxin toxicity.

Higher levels of Endotoxin in circulation place an increased load on the liver and kidneys as the animal works to expel them from their system.

Systemic Endotoxemia

Systemic endotoxemia may play a role in increased susceptibility to other diseases.

Mastitis: most of the economic loss associated with mastitis is due to a reduction in milk production mainly caused by irreversible damage to mammary tissue. Mastitis is among the most common diseases in dairy cattle. Higher loads of LPS may inhibit the migration of neutrophils and cause animals to be more at risk for mastitis infection.

Retained Placenta: The failure to expel placental membranes within 24 hours of calving is largely associated to immune dysfunction. Research suggests that cows exposed to high doses of LPS around parturition are at higher risk of RP.

Metritis, Endometritis, and Infertility: Uterine disease is a key concern for dairy producers and is the most common cause of infertility. Postpartum uterine contamination and immune suppression around parturition are major factors influencing bacterial infection and uterine disease. Exposure to endotoxins during a uterine infection result in long-term consequences to the follicular reserve and may lead to infertility even after resolution of infection.

Fatty Liver: the potential role that endotoxins have on the formation of fatty liver is strongly suggested by multiple studies. Research suggests that high endotoxin loads may result in storage of free fatty acids in the liver.

Displaced Abomasum (DA): Affecting 5-7% of dairy cattle, DA is a multifactorial disease characterized by varying degrees of displacement and distension of the abomasum. The top 3 risk factors for a DA are decreased rumen fill, high-concentrate diets, and increased incidence of other disease such as fatty liver, RP, metritis, and mastitis. Multiple factors point to endotoxins as a contributing factor in the development of a DA. The first being reduced feed intake because of an endotoxin challenge. Endotoxins reduce the motility of the abomasum, making them likely one of the key factors that contributes to this disease.

Milk Fever: an average of 5-10% of all cattle are affected by milk fever (hypocalcemia) postpartum. Approximately 15% of those cattle are unresponsive to treatment resulting in downer cow syndrome. High loads of endotoxin reduce serum Ca and which may make an animal more prone to milk fever and downer cow syndrome. Milk fever remains an issue in the dairy industry despite management of dietary DCAD and magnesium levels. New evidence suggests that immune function is involved in the development of milk fever. More research is needed to clarify the pathway.

Laminitis: inflammation of the dermal layers inside the foot is defined as laminitis.  Laminitis is one of the top 3 diseases causing increased culling of cattle. It is well known that the changes in rumen microbiota caused by acidosis contribute to laminitis, however new research suggests that other factors including hormone changes, endotoxins, and environmental aspects also play a role in the development of laminitis.

Ultimately endotoxins are hard to detect and can cause may health problems.  Solutions to reduce endotoxin load should include management, nutrition, binding of the toxins, support of the liver and kidneys, and modulation of immune function.

Intercept and Intercept FEND support animal health during endotoxin challenges.

  • I.P.S. (Immune Positioning System) a blend of biological polysaccharides and polypeptides.
  • Adsorbents (Yeast Cell Wall, and Montmorillonite Clay).
  • Yucca schidigera modifies rumen fermentation.
  • Dietary nucleotides increase the maturity and growth of normal enterocytes.
  • Live Yeast
  • Yeast Culture
  • Prebiotics
  • Probiotics
  • Postbiotics

For more information on managing toxin challenges on your farm, please reach out to us at service@microbasics.com

 Written by: Mariah Gull, M.S.

Managing Biotoxins – Mycotoxins

Managing Biotoxins – Mycotoxins

The U. N.’s Food and Agriculture Organization (FA) estimates that annually 25% of the world food crops are contaminated with mycotoxins. Mycotoxins are toxic secondary metabolites produced by mold and are harmful to living organisms. Exposure is usually by consumption, contact, or inhalation of contaminated feeds. Negative biological effects because of mycotoxin exposure include liver and kidney toxicity, central nervous system effects, and estrogenic effects.

Mold in feedstuffs

Mold is a fuzzy looking fungus that occurs in feedstuffs. Molds can cause a disease called mycosis that typically occurs when the immune system is suppressed during stressful times. Mycosis can occur in many different locations including the lungs, mammary gland, uterus, or intestine. Intestinal infection may result in hemorrhagic bowel.

Molds also produce poisons called mycotoxins that affect animals when they eat contaminated feeds, resulting in mycotoxicosis.

Mycotoxins in Cattle

Because of degradation in the rumen, cattle are more resistant to mycotoxins than monogastric animals are. Due to greater feed consumption and production stresses, dairy cattle may be more susceptible to mycotoxins than beef cattle.

There are hundreds of mycotoxins known, only a few have been extensively researched.  Mycotoxins of greatest concern most often include ergots produced in small grains, fescue, and grasses. Aflatoxin which is usually produced by Aspergillus mold; deoxynivalenol, zearalenone, T-2 toxin, and fumonisin. Contaminated feeds often contain multiple mycotoxins which alters the expected symptoms of the animal.

Management

Mold spores are in the soil and in plant debris and can grow on crops in the field, during harvest, or during storage, processing or feeding. Management of crop production can reduce the prevalence and concentrations of mycotoxins.

Management of crops can help to reduce the amount of mold and mycotoxin contamination delivered to the animal. Hybrid selection, reduced field and harvest stress, rapid filling of silo bunk or bag, applying a silage inoculant, tight packing, covering, rapid feed-out, and discarding spoiled feed all help to reduce exposure.

Illness

A single dose of mycotoxin can cause an acute toxicity in cattle, but it is more likely that low-level consumption over time will result in more chronic symptoms. Mycotoxins affect cattle by reducing feed consumption, reducing nutrient utilization, altering rumen fermentation, suppressing immunity, altering reproduction, irritating tissues, and causing cellular death. Diagnosis is difficult because mycotoxin residues are not easily detected in the animal and symptoms are nonspecific and may result in a series of events of opportunistic diseases.

Detection

Feed analysis to detect mycotoxins is difficult as it is hard to gather representative feed samples. Not all mycotoxins can be detected by commercial laboratories. Managing the quantity of contaminated feed in a ration can help to reduce the impact of mycotoxins on the animal. See chart below for Mycotoxin Guidelines and Dietary Limits.

POTENTIALLY HARMFUL TOXIN LOADS FOR TOTAL DIET DRY MATTER

 

Dairy

Feedlot

Swine

Poultry

Equine

Toxin Type

All underlined values are in PPM, all others are in PPB

Aflatoxin

20

20

29

20

20

Deoxynivalenol

(DON or Vomitoxin) *

0.5-1.0

10

1

2

500

Fumonisin

2

7

10

20

500

T-2 Toxin

100

500

100

100

50

Zearalenone

400

5

300

10

50

Ochratoxin

5

5

50

100

35

Ergot Toxins (combined)

500

500

500

750

300

*Deoxynivalenol may be used as a marker for other forms of mycotoxin contamination. 90-100% of the time DON is detected with other mycotoxins present.

Measured toxin levels are likely not the only type of toxins present in a sample. Multiple toxins may interact to affect animal health and performance.

Source: Dr. John Goeser, PAS & Dipl. ACAN, Rock River Laboratories

Animal Health and Performance

When we fully understand the problem of mycotoxin contamination, we need to understand that the harmful effects impact overall animal health, performance, and the quality of consumable end products. Solutions to mycotoxin problems must include management, toxin binding, and address immune function.

Intercept and Intercept FEND support animal health during toxin challenges.

  • I.P.S. (Immune Positioning System) a blend of biological polysaccharides and polypeptides.
  • Adsorbents (Yeast Cell Wall, and Montmorillonite Clay).
  • Yucca schidigera modifies rumen fermentation.
  • Dietary nucleotides increase the maturity and growth of normal enterocytes.
  • Live Yeast
  • Yeast Culture
  • Prebiotics
  • Probiotics
  • Postbiotics

 

For more information on managing toxin challenges on your farm, please reach out to us at service@microbasics.com

Written by: Mariah Gull, M.S.